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Systemic infections alter cortical transcriptionalsignatures in Alzheimer’s disease

2025-10-24

Abstract excerpt

Alzheimer’s disease (AD) is characterized by neuroinflammation, yet the impact of concurrent systemic infections on the AD brain remains poorly understood. We investigated the molecular mechanisms underlying the central nervous system response to systemic infections in AD by analyzing RNA sequencing data generated in the prefrontal cortex from 202 post-mortem donors (113 AD, 89 controls), where we stratified by th...

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Identifiers and source

Literature Corpus work
2f1fa62e-7088-5a25-9298-dc7c85d68700
DOI
10.1101/2025.10.23.682825
Open publication

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Systemic infections alter cortical transcriptionalsignatures in Alzheimer’s diseaseDOI 10.1101/2025.10.23.682825
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