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Inhibition of phosphodiesterase 10A by MP-10 rescues behavioral deficits and normalizes microglial morphology and synaptic pruning in a mouse model of FOXP1 syndrome

2024-03-05

Abstract excerpt

<title>Abstract</title> <p>FOXP1 syndrome is caused by <italic>FOXP1</italic> haploinsufficiency and characterized by intellectual disability, speech and language impairment, autistic features and neuropsychiatric abnormalities such as anxiety and hyperactivity. Behavioral changes of respective patients are mirrored in <italic>Foxp1</italic><sup>+/−</sup> mice. In this report, we demonstrate that decreased levels...

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Literature Corpus work
2f0d3507-5c47-516b-b389-6653f0c61fa0
DOI
10.21203/rs.3.rs-3959100/v1
Open publication

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Inhibition of phosphodiesterase 10A by MP-10 rescues behavioral deficits and normalizes microglial morphology and synaptic pruning in a mouse model of FOXP1 syndromeDOI 10.21203/rs.3.rs-3959100/v1
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