Article
Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2.
Journal of neurochemistry - 1 Apr 2008
Sano Hiromi, Nagai Yumiko, Miyakawa Tsuyoshi, Shigemoto Ryuichi, Yokoi Mineto
Abstract excerpt
Cyclic nucleotide phosphodiesterase 10A (PDE10A) is a member of phosphodiesterase families that degrade cAMP and/or cGMP in distinct intracellular sites. PDE10A has a dual activity on hydrolysis of both cAMP and cGMP, and is prominently expressed in the striatum and the testis. Previous studies s...
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