Article

A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats

2023-02-07

Abstract excerpt

<title>Abstract</title> <p>Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with a strong genetic liability. Despite extensive studies, however, the underlying pathogenic mechanism still remains elusive. In the present study, we identified a homozygous mutation in the intron 1 of Wnt1 via large-scale screening of ASD risk/causative genes and verified that this mutation created a new splic...

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Literature Corpus work: 231a5fc5-3c1a-5667-a180-4583a09b63be
DOI: 10.21203/rs.3.rs-2537486/v1

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