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Article

A network map of apelin-mediated signaling

2 Apr 2021

Abstract excerpt

The apelin receptor (APLNR) is a class A (rhodopsin-like) G-protein coupled receptor with a wide distribution throughout the human body. Activation of the apelin/APLNR system regulates AMPK/PI3K/AKT/mTOR and RAF/ERK1/2 mediated signaling pathways. APLNR activation orchestrates several downstream signaling cascades, which play diverse roles in physiological effects, including effects upon vasoconstriction, heart...

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PMID: 33797707
DOI: 10.1007/s12079-021-00614-6

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