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Protein-Specific Signal Peptides for Mammalian Vector Engineering

24 Jul 2023

Abstract excerpt

Expression of recombinant proteins in mammalian cell factories relies on synthetic assemblies of genetic parts to optimally control flux through the product biosynthetic pathway. In comparison to other genetic part-types, there is a relative paucity of characterized signal peptide components, particularly for mammalian cell contexts. In this study, we describe a toolkit of signal peptide elements, created using...

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PMID: 37487508
DOI: 10.1021/acssynbio.3c00157

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