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Article

Structure and sequence engineering approaches to improve in vivo expression of nucleic acid-delivered antibodies.

Molecular therapy : the journal of the American Society of Gene Therapy - 8 Jan 2025

Helble Michaela, Chu Jacqueline, Flowers Kaitlyn, Trachtman Abigail R, Huynh Alana, Kim Amber, Shupin Nicholas, Hojecki Casey E, Gary Ebony N, Solieva Shahlo, Parzych Elizabeth M, Weiner David B, Kulp Daniel W, Patel Ami

Abstract excerpt

Monoclonal antibodies are an important class of biologics with over 160 Food and Drug Administration/European Union-approved drugs. A significant bottleneck to global accessibility of recombinant monoclonal antibodies stems from complexities related to their production, storage, and distribution. Recently, gene-encoded approaches such as mRNA, DNA, or viral delivery have gained popularity, but ensuring...

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Antibodies, Monoclonal
Antibodies, Viral
COVID-19
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Engineering

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Identifiers

PMID: 39563034
DOI: 10.1016/j.ymthe.2024.11.030
PMCID: PMC11764276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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