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Evaluation of different vector design strategies for the expression of recombinant monoclonal antibody in CHO cells

9 Jan 2018

Abstract excerpt

Monoclonal antibodies (mAbs) have emerged as the most promising category of recombinant proteins due to their high efficiency for the treatment of a wide range of human diseases. The complex nature of mAbs creates a great deal of challenges in both upstream and downstream manufacturing processes. Proportional expression and correct folding and assembly of the light chain and heavy chain are required for efficient...

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PMID: 29313429
DOI: 10.1080/10826068.2017.1421966

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