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An innovative platform to improve asymmetric bispecific antibody assembly, purity, and expression level in stable pool and cell line development

2022-10-19

Abstract excerpt

Asymmetric Immunoglobulin G (IgG)-like antibody is a fast-growing class of therapeutics among various bispecific antibody formats. However, the expression of correctly assembled products with high purity and yield remains challenging. Approaches have been investigated to facilitate antibody heterodimerization, including protein engineering, cell line development (CLD) screening, and vector element customization. I...

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Literature Corpus work
952e54dd-8a85-5423-be83-3ca82f017d57
DOI
10.1016/j.bej.2022.108683
Open publication

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An innovative platform to improve asymmetric bispecific antibody assembly, purity, and expression level in stable pool and cell line developmentDOI 10.1016/j.bej.2022.108683
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