Article
Macrophages in multiple myeloma: emerging concepts and therapeutic implications.
Leukemia & lymphoma - 1 Oct 2013
Asimakopoulos Fotis, Kim Jaehyup, Denu Ryan A, Hope Chelsea, Jensen Jeffrey L, Ollar Samuel J, Hebron Ellen, Flanagan Claire, Callander Natalie, Hematti Peiman
Abstract excerpt
Multiple myeloma, a clonal plasma cell malignancy, has long provided a prototypic model to study regulatory interactions between malignant cells and their microenvironment. Myeloma-associated macrophages have historically received limited scrutiny, but recent work points to central and non-redundant roles in myeloma niche homeostasis. The evidence supports a paradigm of complex, dynamic and often mutable...
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