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Article

Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype.

Oncotarget - 30 Nov 2014

Beider Katia, Bitner Hanna, Leiba Merav, Gutwein Odit, Koren-Michowitz Maya, Ostrovsky Olga, Abraham Michal, Wald Hanna, Galun Eithan, Peled Amnon, Nagler Arnon

Abstract excerpt

Multiple myeloma (MM) cells specifically attract peripheral-blood monocytes, while interaction of MM with bone marrow stromal cells (BMSCs) significantly increased monocyte recruitment (p<0.01). The CXCL12 chemokine, produced by both the MM and BMSCs, was found to be a critical regulator of monocyte migration. CXCL12 production was up-regulated under MM-BMSCs co-culture conditions, whereas blockage with...

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Share to Apoptosis
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chemokine CXCL12

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Share to Receptors, CXCR4

Source

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Identifiers

PMID: 25526031
DOI: 10.18632/oncotarget.2207
PMCID: PMC4294328

Genes

CXCL12
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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