Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC

16 May 2018

Abstract excerpt

Multiple myeloma (MM) remains an incurable malignancy despite the recent advancements in its treatment. The protective effects of the niche in which it develops has been well documented; however, little has been done to investigate the MM cell's ability to 're-program' cells within its environment to benefit disease progression. Here, we show that MM-derived macrophage migratory inhibitory factor (MIF) stimulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune cells in cancer
Share to Liver physiology and pathology
Share to Macrophage Migration Inhibitory Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29769142
DOI: 10.1186/s13045-018-0614-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYCPMID 29769142Read ↗

Evaluation of the potential therapeutic benefits of macrophage reprogramming in multiple myelomaSemantic proximity Read ↗

IL-10R Inhibition Reprograms Tumor-Associated Macrophages and Reverses Drug Resistance in Multiple MyelomaSemantic proximity Read ↗

Macrophages in multiple myeloma: emerging concepts and therapeutic implications.Semantic proximity Read ↗

Pathways of Angiogenic and Inflammatory Cytokines in Multiple Myeloma: Role in Plasma Cell Clonal Expansion and Drug ResistanceSemantic proximity Read ↗

Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma CellsSemantic proximity Read ↗

Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironmentSemantic proximity Read ↗

Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype.Semantic proximity Read ↗

Stromal and Endothelial Transcriptional Changes during Progression from MGUS to Myeloma and after Treatment ResponseSemantic proximity Read ↗

Elevated levels of Protein S in Multiple Myeloma bone marrow microenvironment regulate tumor progression and bone diseaseSemantic proximity Read ↗

CXCL7 plays a crucial role in facilitating extramedullary invasion and osteolytic damage in multiple myelomaSemantic proximity Read ↗

How to Reprogram Myeloma-Associated Macrophages: Target IKZF1.Semantic proximity Read ↗

Characterization of in vitro growth of multiple myeloma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.