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Article

The Impact of BDNF, NTRK2, NGFR, CREB1, GSK3B, AKT, MAPK1, MTOR, PTEN, ARC, and SYN1 Genetic Polymorphisms in Antidepressant Treatment Response Phenotypes.

International journal of molecular sciences - 4 Apr 2023

Santos Marlene, Lima Luis, Carvalho Serafim, Mota-Pereira Jorge, Pimentel Paulo, Maia Dulce, Correia Diana, Barroso M Fátima, Gomes Sofia, Cruz Agostinho, Medeiros Rui

Abstract excerpt

This study aimed to investigate the influence of genetic variants in neuroplasticity-related genes on antidepressant treatment phenotypes. The BDNF-TrkB signaling pathway, as well as the downstream kinases Akt and ERK and the mTOR pathway, have been implicated in depression and neuroplasticity. However, clinicians still struggle with the unpredictability of antidepressant responses in depressed patients. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to Receptors, Nerve Growth Factor

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Share to TOR Serine-Threonine Kinases

Source

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Identifiers

PMID: 37047730
DOI: 10.3390/ijms24076758
PMCID: PMC10095078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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