Article
IgG Binding Characteristics of Rhesus Macaque FcγR.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2016
Chan Ying N, Boesch Austin W, Osei-Owusu Nana Y, Emileh Ali, Crowley Andrew R, Cocklin Sarah L, Finstad Samantha L, Linde Caitlyn H, Howell Rebecca A, Zentner Isaac, Cocklin Simon, Miles Adam R, Eckman Joshua W, Alter Galit, Schmitz Joern E, Ackerman Margaret E
Abstract excerpt
Indian rhesus macaques (Macaca mulatta) are routinely used in preclinical studies to evaluate therapeutic Abs and candidate vaccines. The efficacy of these interventions in many cases is known to rely heavily on the ability of Abs to interact with a set of Ab FcγR expressed on innate immune cells. Yet, despite their presumed functional importance, M. mulatta Ab receptors are largely uncharacterized, posing a...
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