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Article

Cloning, expression and characterization of monkey (Macaca fascicularis) CD137.

Veterinary immunology and immunopathology - 15 Dec 2008

Chen Shen-Jue, Foster William R, Jure-Kunkel Maria N, Girit Emel, Abraham Ralph, Hefta Laura J, Gao Shan, Yonan Christopher R, Lin Jun-Hsiang, Dambach Donna M

Abstract excerpt

CD137 plays an important role as a co-stimulatory molecule in activated T cells. Agonistic CD137 specific antibodies have been investigated as therapeutic agents to promote tumor-specific immune responses by direct activation of T cells. As part of the pre-clinical pharmacological evaluation of cynomolgus monkeys, monkey CD137 was cloned and characterized. The deduced amino acid sequence encoded a full-length...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18771806
DOI: 10.1016/j.vetimm.2008.07.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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