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Bispecific CD20xCD40 Antibodies Achieve Multi-Lineage Modulation of Humoral and Cellular Immunity

2025-11-06

Abstract excerpt

Monoclonal antibodies targeting CD20 and CD40 modulate humoral and cellular immunity and have shown therapeutic benefit in B cell malignancies and autoimmune diseases. Here, we describe the generation and preclinical evaluation of two novel bispecific antibodies (DFI201 and DFI205) that combine CD20-mediated B cell depletion inhibition of CD40-mediated influencing populations of B cells, myeloid cells, and T cells...

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Literature Corpus work
dd28ad28-055a-546f-b3bb-2443e9aa9acd
DOI
10.1101/2025.11.04.686640
Open publication

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Bispecific CD20xCD40 Antibodies Achieve Multi-Lineage Modulation of Humoral and Cellular ImmunityDOI 10.1101/2025.11.04.686640
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