Article

Stem cell morphology defines functional heterogeneity and therapeutic vulnerabilities in glioblastoma

2025-03-24

Abstract excerpt

Glioblastoma (GBM) is an aggressive brain tumor and an unmet clinical need due to its invasiveness and therapy resistance. These features are driven by glioblastoma stem cells (GSCs), which exhibit remarkable functional heterogeneity. However, GSC transcriptional profiling alone cannot predict clinically relevant behaviors. Here, we developed CellShape-seq, a spatial transcriptomics platform that integrates cell m...

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Literature Corpus work: 2ee00712-3219-5e0b-ba7c-f53213e9d473
DOI: 10.1101/2025.03.24.644884

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