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Glioblastoma stem cells: Molecular characteristics and therapeutic implications

1 Jan 2014

Abstract excerpt

Glioblastoma Multiforme (GBM) is a grade IV astrocytoma, with a median survival of 14.6 mo. Within GBM, stem-like cells, namely glioblastoma stem cells (GSCs), have the ability to self-renew, differentiate into distinct lineages within the tumor and initiate tumor xenografts in immunocompromised animal models. More importantly, GSCs utilize cell-autonomous and tumor microenvironment-mediated mechanisms to...

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PMID: 24772249
DOI: 10.4252/wjsc.v6.i2.230

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