Article

Is synuclein aggregation a derived or ancestral trait? Ancestral sequence reconstruction uncovers stepwise evolution of synuclein aggregation

2025-09-28

Abstract excerpt

<h4>ABSTRACT</h4> Protein aggregation drives many neurodegenerative diseases, including Parkinson’s disease, where misfolded α-synuclein (αSyn) forms fibrillar assemblies that accumulate as Lewy bodies. Although αSyn aggregation has been extensively characterized, its evolutionary origins and sequence determinants remain unresolved. Here, we use ancestral sequence reconstruction (ASR) to trace the emergence of fi...

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Literature Corpus work: 2eafb473-de46-5f0c-bd88-8613f8d0801b
DOI: 10.1101/2025.09.27.678990

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