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Article

Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease-Associated Markers in 3xtg-AD Mice 

2020-12-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Circulating autoantibodies and sex-dependent discrepancy in prevalence are unexplained phenomena of Alzheimer’s disease (AD). Using the 3xTg-AD mouse model, we reported that adult males show early manifestations of systemic autoimmunity, increased emotional reactivity, enhanced expression of the histone variant macroH2A1 in the cerebral cortex, and loss of plaqu...

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Literature Corpus work
2eaef294-bf96-5b86-b566-8c757564c05a
DOI
10.21203/rs.3.rs-60074/v2
Open publication

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Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease-Associated Markers in 3xtg-AD Mice&nbsp;DOI 10.21203/rs.3.rs-60074/v2
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