Article

Sex Chromosomes and Gonadal Hormones Contribute to B Cell Antibody Responses in Aging and Alzheimer’s Disease

2026-08-25

Abstract excerpt

It is increasingly appreciated that B cell populations in the brain shift during aging and Alzheimer’s Disease (AD), contributing to neuroinflammation and cognitive decline. Though the underlying mechanisms remain unclear, biological sex is likely a key regulator since differences in B cell antibody responses are one of the most well conserved sex differences in immunology. Sex differences in B cell subtypes and a...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: 2a6343f5-fa1d-578f-af90-e7968fee7edb
DOI: 10.64898/2026.08.21.746231

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Sex Chromosomes and Gonadal Hormones Contribute to B Cell Antibody Responses in Aging and Alzheimer’s DiseaseDOI 10.64898/2026.08.21.746231Read

Age, Sex and Alzheimer’s disease: A longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patientsSemantic proximity Read

Differential regulation of mouse hippocampal gene expression sex differences by chromosomal content and gonadal sexSemantic proximity Read

Four Core Genotypes Mice Exhibit Quantitative Differences in T and B Cell Subpopulations compared to Wild-type MiceSemantic proximity Read

Four Core Genotypes and XY* mouse models: Update on impact on SABV research.Semantic proximity Read

Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical ResearchSemantic proximity Read

Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice.Semantic proximity Read

The Importance of Sex Stratification in Autoimmune Disease Biomarker Research: A Systematic Review.Semantic proximity Read

Molecular mechanisms underlying amyloid lowering by aducanumab: differential and comparative effects of sex and IgG reveal the post-treatment disease brainSemantic proximity Read

Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease-Associated Markers in 3xtg-AD Mice Semantic proximity Read

A systems immunology analysis of Alzheimer’s disease reveals an age- and environmental exposure-independent disturbance in B cell maturationSemantic proximity Read

Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer’s disease-associated markers in 3xTg-AD miceSemantic proximity Read

Age- and sex-dependent alterations in the peripheral immune system in the 3xTg-AD mouse model of Alzheimer's disease: Increased proportion of CD3+CD4-CD8- double-negative T cells in the bloodSemantic proximity Read