Article

Protein crosslinking as a therapeutic strategy for SOD1-related ALS

2021-06-23

Abstract excerpt

Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of familial amyotrophic lateral sclerosis (fALS). One effect of these mutations is that SOD1, which is normally a stable dimer, dissociates into toxic monomers. Considerable research efforts have been devoted to developing compounds that stabilize the dimer of fALS SOD1 variants, but these have not yet resulted in an approved drug. W...

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Literature Corpus work: 2eaaee71-4eeb-5df5-9e5c-e92cb1492157
DOI: 10.1101/2021.06.23.449516

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