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Article

Superoxide Dismutase 1 Folding Stability as a Target for Molecular Tweezers in SOD1-Related Amyotrophic Lateral Sclerosis.

Chembiochem : a European journal of chemical biology - 4 Nov 2022

Samanta Nirnay, Ruiz-Blanco Yasser B, Fetahaj Zamira, Gnutt David, Lantz Carter, Loo Joseph A, Sanchez-Garcia Elsa, Ebbinghaus Simon

Abstract excerpt

Protein misfolding and aggregation are hallmarks of many severe neurodegenerative diseases including Alzheimer's, Parkinson's and Huntington's disease. As a supramolecular ligand that binds to lysine and arginine residues, the molecular tweezer CLR01 was found to modify the aggregation pathway of disease-relevant proteins in vitro and in vivo with beneficial effects on toxicity. However, the molecular mechanisms...

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PMID: 36083789
DOI: 10.1002/cbic.202200396
PMCID: PMC9828543

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