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Article

Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.

The Journal of biological chemistry - 10 Oct 2014

Rotunno Melissa S, Auclair Jared R, Maniatis Stephanie, Shaffer Scott A, Agar Jeffrey, Bosco Daryl A

Abstract excerpt

Mutations and aberrant post-translational modifications within Cu,Zn-superoxide dismutase (SOD1) cause this otherwise protective enzyme to misfold, leading to amyotrophic lateral sclerosis (ALS). The C4F6 antibody selectively binds misfolded SOD1 in spinal cord tissues from postmortem human ALS cases, as well as from an ALS-SOD1 mouse model, suggesting that the C4F6 epitope reports on a pathogenic conformation...

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Source

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Identifiers

PMID: 25164820
DOI: 10.1074/jbc.M114.581801
PMCID: PMC4192504

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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