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Article

Ligand-Induced Stabilization of the Native Human Superoxide Dismutase 1.

ACS chemical neuroscience - 7 Jul 2021

Santur Karoline, Reinartz Elke, Lien Yi, Tusche Markus, Altendorf Tim, Sevenich Marc, Tamgüney Gültekin, Mohrlüder Jeannine, Willbold Dieter

Abstract excerpt

A common characteristic of familial (fALS) and sporadic amyotrophic lateral sclerosis (sALS) is the accumulation of aberrant proteinaceous species in the motor neurons and spinal cord of ALS patients-including aggregates of the human superoxide dismutase 1 (hSOD1). hSOD1 is an enzyme that occurs as a stable dimeric protein with several post-translational modifications such as the formation of an intramolecular...

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Identifiers

PMID: 34138531
DOI: 10.1021/acschemneuro.1c00253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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