Article
Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Oct 2011
Sorge Robert E, LaCroix-Fralish Michael L, Tuttle Alexander H, Sotocinal Susana G, Austin Jean-Sebastien, Ritchie Jennifer, Chanda Mona Lisa, Graham Allyson C, Topham Lucas, Beggs Simon, Salter Michael W, Mogil Jeffrey S
Abstract excerpt
The innate immune system is increasingly appreciated to play an important role in the mediation of chronic pain, and one molecule implicated in this process is the Toll-like receptor 4 (TLR4). Here, using pharmacological and genetic manipulations, we found that activating TLR4 in the spinal cord, with the agonist lipopolysaccharide (LPS), causes robust mechanical allodynia but only in male mice. Spinal LPS had no...
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