Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive, Mosaic Expression of TIE2 p.L914F During Mouse Development Causes Venous Malformation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 May 2026

Bischoff Lindsay J, Sherpa Chhiring, Schrenk Sandra, Boscolo Elisa

Abstract excerpt

The hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development and function, drives sporadic venous malformation (VM). While germline or early developmental expression of this mutation is thought to be lethal, mosaic or somatic expression is expected to result in VM disease. However, this has never been shown experimentally. Therefore, we utilized a genetic murine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mosaicism

Share to Mutation

Share to Receptor, TIE-2

Share to Vascular Malformations

Source

Open in PubMed Open full text

Identifiers

PMID: 42059767
DOI: 10.1096/fj.202600444R
PMCID: PMC13159068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive, Mosaic Expression of TIE2 p.L914F During Mouse Development Causes Venous Malformation.PMID 42059767Read ↗

Constitutive, mosaic expression of TIE2 p.L914F during mouse development causes formation of venous malformationSemantic proximity Read ↗

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodelingSemantic proximity Read ↗

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.Semantic proximity Read ↗

Pathogenesis and molecular mechanisms of mutant TIE2-driven venous malformation.Semantic proximity Read ↗

Phenotypic Transition of Vascular Smooth Muscle Cells Induced by Endothelial TIE2 Mutations in Venous MalformationsSemantic proximity Read ↗

Common and specific effects of TIE2 mutations causing venous malformations.Semantic proximity Read ↗

Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte RecruitmentSemantic proximity Read ↗

Venous malformation-causative TIE2 mutations mediate an AKT-dependent decrease in PDGFBSemantic proximity Read ↗

Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expression.Semantic proximity Read ↗

A Patient-Derived Xenograft Model for Venous MalformationSemantic proximity Read ↗

Mouse models of vascular development and diseaseSemantic proximity Read ↗

Variable Somatic TIE2 Mutations in Half of Sporadic Venous MalformationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.