Article

Beyond Annotation: Leveraging Raw RNA-seq Reads via Foundation Models for Multi-Cancer Early Detection

2025-12-18

Abstract excerpt

Early cancer detection substantially improves patient survival, yet conventional screening methods are directed at single anatomical sites and inadequately screen 45.5% of cases. Cell-free RNA (cfRNA) from blood offers a promising, non-invasive avenue for early cancer detection, reflecting real-time transcriptional activity from tumors. However, most RNA-seq pipelines focus exclusively on annotated genes, ignoring...

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Literature Corpus work: c2fbdea3-45f6-55c5-bb8e-37d414248636
DOI: 10.64898/2025.12.17.25342371

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