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Article

A dual context-aware basecaller for nanopore direct RNA sequencing.

Nature communications - 21 Jan 2026

Xie Shaohui, Ding Lulu, Yu Yang, Liu Ling, Sun Yiwen, Li Jianqiang, Ruan Jue, Zhu Zexuan

Abstract excerpt

Nanopore direct RNA sequencing (DRS) offers distinct advantages for transcriptome analysis over the traditional high-throughput RNA sequencing methods by preserving native RNA modifications, eliminating polymerase chain reaction bias, and simplifying the workflow. However, its high basecalling error rate remains a significant hurdle. Here we introduce Coral, a dual context-aware nanopore DRS basecaller that uses...

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Identifiers

PMID: 41565691
DOI: 10.1038/s41467-026-68566-2
PMCID: PMC12920642

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