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Article

Large neutral amino acid levels tune perinatal neuronal excitability and survival.

Cell - 27 Apr 2023

Knaus Lisa S, Basilico Bernadette, Malzl Daniel, Gerykova Bujalkova Maria, Smogavec Mateja, Schwarz Lena A, Gorkiewicz Sarah, Amberg Nicole, Pauler Florian M, Knittl-Frank Christian, Tassinari Marianna, Maulide Nuno, Rülicke Thomas, Menche Jörg, Hippenmeyer Simon, Novarino Gaia

Abstract excerpt

Little is known about the critical metabolic changes that neural cells have to undergo during development and how temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically essential large neutral amino acids (LNAAs), lead to autism, we employed metabolomic profiling to study the metabolic states of the cerebral...

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PMID: 36996814
DOI: 10.1016/j.cell.2023.02.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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