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Article

Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.

Cell reports - 25 Oct 2012

Almeida Sandra, Zhang Zhijun, Coppola Giovanni, Mao Wenjie, Futai Kensuke, Karydas Anna, Geschwind Michael D, Tartaglia M Carmela, Gao Fuying, Gianni Davide, Sena-Esteves Miguel, Geschwind Daniel H, Miller Bruce L, Farese Robert V, Gao Fen-Biao

Abstract excerpt

The pathogenic mechanisms of frontotemporal dementia (FTD) remain poorly understood. Here we generated multiple induced pluripotent stem cell lines from a control subject, a patient with sporadic FTD, and an FTD patient with a novel heterozygous GRN mutation (progranulin [PGRN] S116X). In neurons and microglia differentiated from PGRN S116X induced pluripotent stem cells, the levels of intracellular and secreted...

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Identifiers

PMID: 23063362
DOI: 10.1016/j.celrep.2012.09.007
PMCID: PMC3532907

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GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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