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Article

General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia

31 Aug 2006

Abstract excerpt

Ciliary localization of the transient receptor potential polycystin 2 channel (TRPP2/PKD-2) is evolutionarily conserved, but how TRPP2 is targeted to cilia is not known. In this study, we characterize the motility and localization of PKD-2, a TRPP2 homolog, in C. elegans sensory neurons. We demonstrate that GFP-tagged PKD-2 moves bidirectionally in the dendritic compartment. Furthermore, we show a requirement for...

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PMID: 16943275
DOI: 10.1242/dev.02555

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