Article
Identification of genes involved in the ciliary trafficking of C. elegans PKD-2.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2008
Bae Young-Kyung, Lyman-Gingerich Jamie, Barr Maureen M, Knobel Karla M
Abstract excerpt
Ciliary membrane proteins are important extracellular sensors, and defects in their localization may have profound developmental and physiological consequences. To determine how sensory receptors localize to cilia, we performed a forward genetic screen and identified 11 mutants with defects in the ciliary localization (cil) of C. elegans PKD-2, a transient receptor potential polycystin (TRPP) channel. Class A cil...
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