Article

HuR enhances SARS-CoV-2 non-structural protein translation through the genomic 5’-UTR, by promoting polypyrimidine tract-binding protein binding

2023-03-16

Abstract excerpt

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) viral RNA associates with different RNA-binding host proteins at each stage of its life cycle. We found sequence dependent binding of one such important protein, human antigen R (HuR) to SARS-CoV-2 5′UTR and studied its potential role in virus life cycle. The knockdown and knockout studies revealed importance of such binding in viral translation. We iden...

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Literature Corpus work: 97f37322-819e-5f9c-a8ab-ab8c17a28c4e
DOI: 10.1101/2023.03.15.532790

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HuR enhances SARS-CoV-2 non-structural protein translation through the genomic 5’-UTR, by promoting polypyrimidine tract-binding protein bindingDOI 10.1101/2023.03.15.532790Read

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