Article
Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A.
Nature communications - 21 Jul 2020
Camacho-Zarco Aldo R, Kalayil Sissy, Maurin Damien, Salvi Nicola, Delaforge Elise, Milles Sigrid, Jensen Malene Ringkjøbing, Hart Darren J, Cusack Stephen, Blackledge Martin
Abstract excerpt
Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. Adaptive mutants are localised on the C-terminal (627-NLS) domains of the PB2 subunit. In particular, mutation of PB2 residue 627 from E to K rescues polymerase activity in mammalian cells. A host transcription regulator ANP32A, comprising a long C-terminal intrinsically disordered domain (IDD), is responsible...
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