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Article

A natural variant in ANP32B impairs influenza virus replication in human cells.

The Journal of general virology - 1 Sept 2021

Staller Ecco, Sheppard Carol M, Baillon Laury, Frise Rebecca, Peacock Thomas P, Sancho-Shimizu Vanessa, Barclay Wendy S

Abstract excerpt

Viruses require host factors to support their replication, and genetic variation in such factors can affect susceptibility to infectious disease. Influenza virus replication in human cells relies on ANP32 proteins, which are involved in assembly of replication-competent dimeric influenza virus polymerase (FluPol) complexes. Here, we investigate naturally occurring single nucleotide variants (SNV) in the human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34524075
DOI: 10.1099/jgv.0.001664
PMCID: PMC8567425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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