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Article

Causal association of genetically predicted 1400 blood metabolites with inflammatory bowel disease risk: A Mendelian randomization study.

Medicine - 27 Mar 2026

Huang Lin, Hao Wenzhe, Fang Xiaoli, Wang Jianmin, Shi Yang, Li Zilong, Ye Hao, Li Ming

Abstract excerpt

We utilized an unbiased 2-sample Mendelian randomization approach to investigate the potential causal relationship between 1400 human blood metabolites and the risk of inflammatory bowel disease (IBD). Exposure data were sourced from the largest metabolome-based genome-wide association study (mGWAS), which included 8299 individuals from Canada. The results were primarily derived from a meta-analysis of...

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Canada
Genetic Predisposition to Disease
Genome-Wide Association Study
Inflammatory Bowel Diseases
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 41894296
DOI: 10.1097/MD.0000000000048132
PMCID: PMC13034940

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