Article
A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review.
The Journal of clinical endocrinology and metabolism - 18 Aug 2023
Besci Özge, Fırat Sevde Nur, Özen Samim, Çetinkaya Semra, Akın Leyla, Kör Yılmaz, Pekkolay Zafer, Özalkak Şervan, Özsu Elif, Erdeve Şenay Savaş, Poyrazoğlu Şükran, Berberoğlu Merih, Aydın Murat, Omma Tülay, Akıncı Barış, Demir Korcan, Oral Elif Arioglu
Abstract excerpt
CONTEXT: Homozygous leptin (LEP) and leptin receptor (LEPR) variants lead to childhood-onset obesity. OBJECTIVE: To present new cases with LEP and LEPR deficiency, report the long-term follow-up of previously described patients, and to define, based on all reported cases in literature, genotype-phenotype relationships. METHODS: Our cohort included 18 patients (LEP = 11, LEPR = 7), 8 of whom had been previously...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.