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Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in<i>Abca4<sup>−/−</sup>Rdh8<sup>−/−</sup></i>Mice After Light Exposure

17 Jun 2016

Abstract excerpt

PURPOSE: Mice lacking ATP-binding cassette transporter 4 (ABCA4) and retinol dehydrogenase 8 (RDH8) mimic features of human Stargardt disease and age-related macular degeneration. RNA-sequencing of whole eyes was done to study early gene expression changes in Abca4-/-Rdh8-/- mice. METHODS: Abca4-/-Rdh8-/- mice at 4 weeks of age were exposed to intense light. Total RNA was extracted from whole eyes and used to...

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PMID: 27315541
DOI: 10.1167/iovs.15-18993

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