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Article

Integrating Genomic, eQTL, and Mendelian Randomization Analyses to Identify Microglial Drug Targets in Multiple Sclerosis.

Journal of cellular and molecular medicine - 1 Nov 2025

Yan Wu, Wen Jiang, Jianhong Wang

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease characterised by neuroinflammation and neurodegeneration. This study investigates genetic and immunological factors in MS, focusing on microglial regulation. We analysed differentially expressed genes using RNA sequencing from MS lesions (GSE108000) and plaques (GSE227781), validated with cis-eQTL analysis, and integrated Mendelian randomisation (MR), SMR,...

Topics

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Genomics
HLA-DRB1 Chains
Mendelian Randomization Analysis
Microglia
Multiple Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Interaction Maps

Quantitative Trait Loci

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Identifiers

PMID: 41239018
DOI: 10.1111/jcmm.70754
PMCID: PMC12618184

Genes

SYK
ARHGAP25
MERTK
MS4A6A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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