Article

Inhibition of autophagy as a novel therapy for the treatment of neurofibromatosis type 1 tumors

2021-12-20

Abstract excerpt

<h4>ABSTRACT</h4> Neurofibromatosis type 1 (NF1) is a genetic disorder associated with various symptoms including the formation of benign tumors along nerves. Drug treatments are currently limited. The MEK inhibitor selumetinib is used for a subset of cases but is not always effective and can cause side effects. Therefore, there is a clear need to discover new drugs to target NF1 -deficient tumor cells. Using a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8b10361-6799-5f99-ac75-54ad0bb2b79c
DOI: 10.1101/2021.12.20.473481

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of autophagy as a novel therapy for the treatment of neurofibromatosis type 1 tumorsDOI 10.1101/2021.12.20.473481Read

The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cellsSemantic proximity Read

A novel combinatorial treatment for Neurofibromatosis type 1 tumours revealed through cross-species genetic analysisSemantic proximity Read

A novel combinatorial treatment for Neurofibromatosis type 1 tumours revealed through cross-species genetic analysisSemantic proximity Read

Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumorsSemantic proximity Read

Neurofibromatosis Type 1 and MEK Inhibition: A Comprehensive Review with Focus on Selumetinib TherapySemantic proximity Read

Systematic analysis uncovers SYK dependency in NF1 <sup>LoF</sup> melanoma cellsSemantic proximity Read

The Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity <i>In vitro</i> and <i>In vivo</i>Semantic proximity Read

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN lossSemantic proximity Read

New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors.Semantic proximity Read

Drug Responses in Plexiform Neurofibroma Type I (PNF1) Cell Lines Using High-Throughput Data and Combined Effectiveness and PotencySemantic proximity Read

A targeted, low-throughput compound screen in a <i>Drosophila</i> model of neurofibromatosis type 1 identifies simvastatin and BMS-204352 as potential therapies for autism spectrum disorder (ASD)Semantic proximity Read

Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD–Dependent MannerSemantic proximity Read