Article

Deconvolving clinically relevant cellular immune crosstalk from bulk gene expression using CODEFACS and LIRICS

2021-01-21

Abstract excerpt

The tumor microenvironment (TME) is a complex mixture of cell types whose interactions affect tumor growth and clinical outcome. To discover such interactions, we developed CODEFACS (COnfident DEconvolution For All Cell Subsets), a tool deconvolving cell-type-specific gene expression in each sample from bulk expression, and LIRICS (LIgand Receptor Interactions between Cell Subsets), a statistical framework priorit...

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Literature Corpus work: 2dd77fa4-7606-5138-a35c-a2a1e2fe2fed
DOI: 10.1101/2021.01.20.427515

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