Article

Data-driven inference of crosstalk in the tumor microenvironment

2019-11-08

Abstract excerpt

Signaling between cancer and nonmalignant (stromal) cells in the tumor microenvironment (TME) is key to tumorigenesis yet challenging to decipher from tumor transcriptomes. Here, we report an unbiased, data-driven approach to deconvolute bulk tumor transcriptomes and predict crosstalk between ligands and receptors on cancer and stromal cells in the TME of 20 solid tumor types. Our approach recovers known transcrip...

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Identifiers and source

Literature Corpus work: c9926382-c678-5058-abe3-da30cdff5eb3
DOI: 10.1101/835512

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