Article

Influence of family history on penetrance of hereditary cancers in a population setting

2022-07-09

Abstract excerpt

<h4>Background</h4> We sought to investigate how penetrance of familial cancer syndromes varies with family history using a population-based cohort. <h4>Methods</h4> We analysed 454,712 UK Biobank participants with exome sequence and clinical data. We identified participants with a self-reported family history of breast or colorectal cancer and a pathogenic/likely pathogenic variant in the major genes responsible...

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Literature Corpus work: 2db1fc77-3c16-5c01-9664-4b61f4b84735
DOI: 10.1101/2022.07.08.22277415

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