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Cancer Spectrum and Gene-Specific Patterns in Lynch Syndrome: Insights From 47 Families in a Brazilian Institutional Cohort.

JCO global oncology - 1 May 2026

Bassaneze Thiago, Oliveira Ferreira Fábio, Sandoval Renata Lazari, Pisani Janina Pontes, Vanessa Quirino Carla, Rodrigues de Nicola Pablo Domingos, Achatz Maria Isabel, Dominguez-Valentin Mev, Rossi Benedito Mauro

Abstract excerpt

PURPOSE: To characterize tumor-site distribution, age at diagnosis, sex distribution, and tumor multiplicity in a Brazilian institutional Lynch syndrome (LS) cohort stratified by mismatch repair (MMR) gene and genetic testing status, and to assess the impact of including nontested (NT) relatives. METHODS: We conducted a retrospective, registry-based family cohort study of families ascertained in 2013-2019 with...

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Identifiers

PMID: 42160694
DOI: 10.1200/GO-25-00708

Genes

MSH2
MLH1
EPCAM
MSH6
PMS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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