Influence of family history on penetrance of hereditary cancers in a population setting

Abstract excerpt

Background We sought to investigate how penetrance of familial cancer syndromes varies with family history using a population-based cohort. Methods We analysed 454,712 UK Biobank participants with exome sequence and clinical data (data collected between March 2006 and June 2021). We identified participants with a self-reported family history of breast or colorectal cancer and a pathogenic/likely pathogenic...

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