Article

X-Chromosome-Wide Association Study Identifies Novel Genetic Signals for Heart Failure and Subtypes

2026-04-23

Abstract excerpt

<h4>Background</h4> Heart failure (HF) is a major and growing public health problem, and prior studies support a meaningful genetic contribution to HF susceptibility. Clinically, HF is commonly categorized into the major clinical sub-types of HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), which differ in pathophysiology and clinical profiles. However, previous genome-wi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2da69bda-8afd-56a1-9c1a-df58415d2d7c
DOI: 10.64898/2026.04.21.26351435

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

X-Chromosome-Wide Association Study Identifies Novel Genetic Signals for Heart Failure and SubtypesDOI 10.64898/2026.04.21.26351435Read

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.Semantic proximity Read

Mapping the aetiological foundations of the heart failure spectrum using human geneticsSemantic proximity Read

Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic DiscoverySemantic proximity Read

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart FailureSemantic proximity Read

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failureSemantic proximity Read

The Genetic Factors Influencing Cardiomyopathies and Heart Failure across the Allele Frequency Spectrum.Semantic proximity Read

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failureSemantic proximity Read

Genetic Architecture of Heart Failure with Preserved versus Reduced Ejection FractionSemantic proximity Read

Integrated Multiomics Approach to Identify Genetic Underpinnings of Heart Failure and Its Echocardiographic Precursors: Framingham Heart Study.Semantic proximity Read

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese populationSemantic proximity Read

Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure.Semantic proximity Read

Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with Pathophysiological Relevance to Heart FailureSemantic proximity Read