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Article

Multi-ancestry genetic architecture of heart failure subtypes.

Nature communications - 13 Aug 2026

Liu Chang, Hui Qin, Linchangco Gregorio V, Wells Quinn S, Farber-Eger Eric, Rasooly Danielle, Michael Gaziano J, Wilson Peter W F, Quyyumi Arshed A, Vaccarino Viola, Hu Yi-Juan, Benkeser David, Ito Kaoru, Enzan Nobuyuki, Phillips Lawrence S, Joseph Jacob, Sun Yan V

Abstract excerpt

Heart failure (HF) affects 6.7 million people in the US and includes two major subtypes, HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), with distinct genetic architectures. We meta-analyze genome-wide association studies (GWAS) of 38,781 HFrEF cases, 38,163 HFpEF cases, and 526,135 controls across European, African, Hispanic, and Asian ancestries using the Million...

Read the complete abstract on PubMed

Topics

Humans
Gene Frequency
Genetic Predisposition to Disease
Genome-Wide Association Study
Heart Failure

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hispanic or Latino

Polymorphism, Single Nucleotide

Stroke Volume

White

Asian

Black or African American

Veterans

Source

Open in PubMed Open full text

Identifiers

PMID: 42722677
DOI: 10.1038/s41467-026-76438-y
PMCID: PMC13562571

Genes

CD36
SPI1
SPNS3
TRIM48

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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