Mutational Profiles of Cutaneous Squamous Cell Carcinomas with Different Patterns of Clinical Aggression from Head and Neck District

Abstract excerpt

Cutaneous squamous cell carcinoma is a prevalent malignancy with a rising incidence and notably high mutational load. Exploring the genetic nuances of cSCC and investigating molecular approaches stands as a potential avenue for improving outcome in high-risk patients. This retrospective case-control study involved two cohorts of 14 patients (“discovery cohort”) and 12 patients (“validation cohort”) with cSCC locat...

Topics

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• Carcinoma, Squamous Cell
• DNA Methylation
• Epigenesis, Genetic
• Gene Expression Regulation, Neoplastic
• Mutation
• Mutation Rate
• RNA, Untranslated
• Skin Neoplasms

Identifiers and source

Literature Corpus work

2d69edb8-d957-529e-9686-a44698fdb1c0

DOI

10.20944/preprints202405.0417.v1