Article
Differential mutation frequencies in metastatic cutaneous squamous cell carcinomas versus primary tumors.
Cancer - 1 Apr 2017
Yilmaz Ayse Selen, Ozer Hatice Gulcin, Gillespie Jessica L, Allain Dawn C, Bernhardt Madison N, Furlan Karina Colossi, Castro Leticia T F, Peters Sara B, Nagarajan Priyadharsini, Kang Stephen Y, Iwenofu O Hans, Olencki Thomas, Teknos Theodoros N, Toland Amanda Ewart
Abstract excerpt
BACKGROUND: Exome and targeted sequencing studies have identified potential driver mutations for a variety of tumor types. Cutaneous squamous cell carcinoma (cSCC) is one of the most highly mutated cancers but typically is associated with low rates of metastasis and high survival rates. Nevertheless, metastatic cSCC is a significant health threat; up to 8800 individuals die each year of this disease. METHODS:...
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